The Great Commandment Matthew 22:34-40 But when the Pharisees had heard that he put Sadducees to silence they were gathered together. Then one of them which was a lawyer asked him question tempting him and saying Master is great commandment in law? Jesus said unto Thou shalt love Lord thy God with all heart soul mind. This first commandment. And second like it neighbour as thyself. On these two commandments hang law prophets.