Post-translational Modifications ELK-1 ALS Therapeutic Potential Neuroprotective PTM Mimetic Peptides Mechanistic investigation Stevia rebaudiana SIRT1 INS-1E cell model inulin-rich extracts type 2 diabetes mitochondria Transplantation Sepsis Muscle atrophy Biomarkers Neurodegenerative disease proteomics Everolimus ABT-737 renal carcinoma Purification Characterization Fermentation Rebaudiana Colon