Cystic Fibrosis TRL Activation Proinflammatory Cytokine Tissue Damage Mucus Hypersecretion Eosinophil Infiltration Protease-antiprotease Imbalance Reduced Mitochondrial ATP Production Endothelial Dysfunction Asthma COPD Neutrophils Macrophages Bronchoconstriction Emphysema Comorbidity Hyperinflammation